Target Practice

Researchers shoot for new treatments against tuberculosis

In the “The Three Little Pigs,” the wisest pig protects himself by building the house with the strongest walls. In the world of bacteria, the microbe that causes tuberculosis employs a similar strategy. Mycobacterium tuberculosis packs extra layers of sugars and lipids into its cell wall to make a structure almost impenetrable by human–immune system defenses and by many antibiotics.