DNA disorganization linked to aging

Study of adult progeria gene shows that resulting cell chaos leads to graying hair, brittle bones

NUCLEAR DISARRAY  Normally tightly packed bundles of DNA (as in the normal stem cells, left) come undone in cells that age prematurely (right), enlarging their nuclei and promoting aging.

Zhang et al/Science 2015; Reprinted with permission from AAAS

Old cells do not go gently into that good night.