Weight loss surgery causes bacteria in the intestines to extract fewer calories from food, a new study suggests.
Changes to the gut microbiome last at least nine years after Roux-en-Y gastric bypass or gastric banding surgery, scientists report in the Aug. 4 Cell Metabolism. Groups of women who had either gastric bypass or an operation called vertical banded gastroplasty both had long-lasting changes to their microbiomes regardless of how much weight they lost.
Researchers transplanted bacteria from obese women and from women who had the surgeries into mice raised without gut microbes. Mice with gut bacteria from the surgery groups gained less body fat than did rodents with microbes transplanted from obese women.
Gastric bypass in particular switched the metabolism of microbes so that they burned fewer carbohydrates and more fat, the scientists write.