Putting the brakes on toxic shock
By Nathan Seppa
Scientists in Sweden have discovered the cascade of molecular events that underpins many cases of toxic shock syndrome. The researchers have even successfully foiled this deadly sequence in animals, suggesting that a similar approach might benefit people.
Some cases of toxic shock syndrome arise from streptococcus infections. In these, a bacterial protein called M protein incites massive leakage from blood vessels. Blood pressure plummets, throwing the body into shock, while blood-starved organs fail. Fatality rates range from 30 percent to 70 percent.